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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
14.24
Human Site:
S106
Identified Species:
22.38
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
S106
T
I
Q
S
D
G
I
S
D
S
E
K
C
S
P
Chimpanzee
Pan troglodytes
XP_524527
588
65774
S106
T
I
Q
S
D
G
I
S
D
S
E
K
C
S
P
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
S106
T
V
Q
S
D
G
I
S
D
S
E
K
C
S
P
Dog
Lupus familis
XP_537131
637
71340
N156
T
L
Q
S
D
G
I
N
D
S
E
K
C
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
I105
N
T
L
Q
S
D
G
I
S
N
S
E
K
S
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
V105
S
T
L
Q
S
D
G
V
S
N
S
E
K
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
S88
G
S
A
G
S
L
K
S
L
E
G
G
G
R
P
Chicken
Gallus gallus
Q5ZIU3
526
59419
Y88
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
T
F
Frog
Xenopus laevis
NP_001088793
567
63329
S86
R
V
G
A
G
V
P
S
T
E
S
A
F
P
L
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
P97
H
N
G
T
S
Q
V
P
A
K
P
P
P
A
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
K174
C
E
S
L
I
S
V
K
E
S
S
V
M
E
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
K358
T
H
D
M
M
H
S
K
I
P
K
S
P
S
N
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
I90
R
Q
V
Q
N
K
V
I
A
N
G
H
L
S
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
T41
P
R
K
R
P
R
L
T
W
D
A
A
P
P
L
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
S218
N
Y
S
S
N
F
S
S
L
N
S
N
T
N
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
93.3
86.6
N.A.
6.6
6.6
N.A.
13.3
6.6
6.6
0
N.A.
6.6
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
20
26.6
N.A.
13.3
26.6
20
20
N.A.
20
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
14
0
0
0
0
14
0
7
14
0
7
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
27
0
0
% C
% Asp:
0
0
7
0
27
14
0
0
27
7
0
0
0
0
0
% D
% Glu:
0
14
0
0
0
0
0
0
7
14
27
14
0
7
0
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
7
% F
% Gly:
7
0
14
7
7
27
14
0
0
0
14
7
7
0
0
% G
% His:
7
7
0
0
0
7
0
0
0
0
0
7
0
0
7
% H
% Ile:
0
14
0
0
7
0
27
14
7
0
0
0
0
0
7
% I
% Lys:
0
0
7
0
0
14
7
14
0
7
14
27
14
0
0
% K
% Leu:
0
7
14
7
0
7
7
0
14
0
0
7
7
0
14
% L
% Met:
0
0
0
7
14
0
0
0
7
0
0
0
7
0
0
% M
% Asn:
14
7
0
0
14
0
0
7
0
27
0
7
0
7
14
% N
% Pro:
14
0
0
0
7
0
7
7
0
7
7
7
20
14
34
% P
% Gln:
0
7
34
20
0
7
7
0
0
7
0
0
0
0
7
% Q
% Arg:
14
7
0
7
0
7
0
0
0
0
0
0
0
7
0
% R
% Ser:
7
7
14
34
27
7
14
40
14
34
34
7
0
54
14
% S
% Thr:
34
14
0
7
0
0
0
7
7
0
0
0
14
7
0
% T
% Val:
0
14
7
0
0
7
20
7
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _